Why do phase III trials of promising heart failure drugs often fail? the contribution of “regression to the truth”
Author:
Publisher
Elsevier BV
Subject
Cardiology and Cardiovascular Medicine
Reference18 articles.
1. Clinical trials update: RENEWAL (RENAISSANCE and RECOVER) and ATTACH;Coletta;Eur J Heart Fail,2002
2. Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?;Kalra;Int J Cardiol,2002
3. Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE);Packer;Circulation,2002
4. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure. Vesnarinone Trial Investigators;Cohn;N Engl J Med,1998
5. Effects of vesnarinone on morbidity and mortality in patients with heart failure. Vesnarinone Study Group;Feldman;N Engl J Med,1993
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