Trimethylsulfonium: a promising new biomarker for hydrogen sulfide?-Reference-Cited by-同舟云学术

Trimethylsulfonium: a promising new biomarker for hydrogen sulfide?

Published:2022-07-20 Issue: Volume: Page:1-4
ISSN:2612-1344
Container-title:Journal of Advanced Health Care
language:it
Short-container-title:JAHC

Author:

Lajin Bassam¹^ORCID,Somma Renato²^ORCID

Affiliation:

1. Institute of Chemistry, Analytical Chemistry for the Health and Environment, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria

2. INGV Osservatorio Vesuviano Via Diocleziano, 328 - 80124 Napoli Italy -CNR Istituto di Ricerca su Innovazione e Servizi per lo Sviluppo Via G. Sanfelice, 8 – 80134 Napoli, Italy

Abstract

Hydrogen sulfide is a toxic gas but is naturally produced in human tissues and is referred to as the “third gaseous signaling molecule”. Little is known about the metabolic pathways of hydrogen sulfide and its endogenous natural production in humans. Thiosulfate is the currently used biomarker for hydrogen sulfide but its utility has been shown to be limited to exposure to high levels of inhaled hydrogen sulfide rather than probing low levels of environmental exposure or as a biomarker for the endogenously produced third gaseous signaling molecule. We recently identified a new metabolite in human urine, trimethylsulfonium. In the present review, we discuss the little information known about trimethylsulfonium production in humans, its potential to serve as a biomarker for hydrogen sulfide, and its utility as a biomarker under various settings.

Publisher

Ordine TSRM PSTRP di Napoli, Avellino, Benevento

Subject

Earth-Surface Processes

Reference24 articles.

1. Kabil O & Banerjee R (2014) Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal 20(5):770-782.

2. Kabil O, Vitvitsky V, & Banerjee R (2014) Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr 34:171-205.

3. Vitvitsky V, Kabil O, & Banerjee R (2012) High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations. Antioxid Redox Signal 17(1):22-31.

4. Furne J, Saeed A, & Levitt MD (2008) Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295(5):R1479-R1485.

5. Hildebrandt TM & Grieshaber MK (2008) Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria. FEBS J 275(13):3352-3361.