STRUCTURE-ACTIVITY RELATIONSHIP OF 5,6-DIHYDRO-TETRAZOLO[1,5-c]QUINAZOLINES TARGETING CANDIDA GLABRATA-Reference-Cited by-同舟云学术

STRUCTURE-ACTIVITY RELATIONSHIP OF 5,6-DIHYDRO-TETRAZOLO[1,5-c]QUINAZOLINES TARGETING CANDIDA GLABRATA

Published:2024-03-25 Issue:37 Volume: Page:474-477
ISSN:2710-3056
Container-title:Grail of Science
language:
Short-container-title:GoS

Author:

Antypenko Lyudmyla^ORCID,Antypenko Oleksii^ORCID,Vasilieva Inna,Kozyrieva Valentyna

Abstract

Candida species cause both disseminated and superficial fungal infections in humans. Although azole antifungals have historically proven effective in treating such infections, recent epidemiological studies highlight a crucial concern in the clinical context. Some Candida species exhibit inherent resistance to azoles and echinocandins, and the emergence of high-level resistance poses a significant problem. Consequently, derivatives of 5,6-dihydrotetrazolo[1,5-c]quinazolines have shown potent inhibitory properties against C. glabrata at concentrations range of 0.4 – 55.0 μM, leading to the identification of a structure-activity relationship.

Publisher

European Scientific Platform (Publications)

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