ALLOSTERIC SITE OF SERINE PROTEINASES: LOCALIZATION, FUNCTIONAL ROLE AND MANIFESTATIONS IN VITRO

Abstract

The study of molecular mechanisms of regulation of biologically active molecules is a necessary condition for understanding the course of the processes mediated by them. Serine proteinases are a large group of enzymes that play a leading role in the regulation of numerous physiological and pathogenic processes. Like many enzymes, SP are allosteric ones. In addition to the active center, they contain the region, whose interaction with corresponding compound changes the activity of enzyme. Various compounds can act as allosteric effectors. They may be substrates, substrate-like compounds, and mimics of some fragments of substrates. Taking into account the importance of serine proteases’ functions, it’s deserve attention the systematic data on localization, functional role and manifestations of allosteric region.