A Case Report of EGFR-mutated Metastatic Lung Adenocarcinoma with Long-term Survival on Systemic Treatment-Reference-Cited by-同舟云学术

A Case Report of EGFR-mutated Metastatic Lung Adenocarcinoma with Long-term Survival on Systemic Treatment

Published:2021-03-22 Issue:1 Volume:1 Page:51-58
ISSN:2784-0131
Container-title:Journal of Medical and Radiation Oncology
language:
Short-container-title:JMRO

Author:

Dulf Daniel¹,Kubelak Paul¹,Iancu Dana¹,Ciuleanu Tudor-Eliade²

Affiliation:

1. Institute of Oncology "Prof. Dr. Ion Chiricuță", Cluj-Napoca, Romania

2. "“Ion Chiricuță” Institute of Oncology, Cluj-Napoca, Romania 2 UMF “Iuliu Hațieganu” Cluj-Napoca, Romania"

Abstract

"Metastatic non-small cell lung cancer has historically been associated with a poor prognosis. The introduction of targeted agents against certain molecules involved in cellular pathways has shown improved responses, but long-term survivors are still rare. We present the case of a patient with lung adenocarcinoma harboring sensitizing EGFR mutations who showed an impressive survival of more than 9 years following a combination of systemic therapies consisting of cytotoxic drugs and EGFR TKIs that were very well tolerated."

Publisher

Asociatia Societatea Transdisciplinara de Oncologie Personalizata Pentru Combaterea Cancerului - Stop Cancer

Reference14 articles.

1. "1. Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy and supportive care versus supportive care alone for advanced non-small-cell lung cancer. Cochrane Database Syst Rev 2010;12:CD007309.

2. 2. B. Asselain, J.-R. Barrière, C. Clarot, J.-P. Vabre, B. Gentil Le Pecq, Y. Duval, P. Thomas, D. Herman, M. Grivaux, D. Debieuvre. Metastatic NSCLC: Clinical, molecular, and therapeutic factors associated with long-term survival, Respiratory Medicine and Research, Volume 76,2019,

3. 3. Levi-Montalcini, R., and Cohen, S. (1960) Effects of the extract of the mouse submaxillary salivary glands on the sympathetic system of mammals. Ann. NY Acad. Sci. 85, 324–341.

4. 4. Cohen, S. and Carpenter, G. (1975) Human epidermal growth factor: isolation and chemical and biological properties. Proc. Natl. Acad. Sci. USA 72, 1317–1321.

5. 5. Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 Jun 4;304(5676):1497-500