L’angioedema istaminergico idiopatico (ricorrente)

Abstract

Angioedema is defined as a transient and localized swelling due to the release either in the subcutis, submucosa or both of vasoactive substances that increase vascular permeability and induce vasodilation. It is usually associated with urticaria, but it can also be isolated and identified as a sign of a distinct entity with different clinical expression, according to the main mediator underlying the oedema: histamine or bradykinin. Bradykinin is linked to the best-known hereditary angioedema whereas histamine is the main mediator of allergic angioedema, usually associated with urticaria (and/or other IgE-mediated symptoms), and of histaminergic angioedema without urticaria, the most common of which is idiopathic histaminergic acquired angioedema.