Affiliation:
1. IRCCS Ospedale Pediatrico “Bambino Gesù”, Roma
Abstract
Fever is a very common symptom in children, mostly due to infections. It is a physiological body defence mechanism against damage. However, when it is recurring, it is difficult to understand which are the underlying causes. Recurrent fever is most commonly due to trivial infections of the 1st infancy. However, it can seldom be the expression of inborn errors of immunity, monogenic periodic fevers, neoplasm, or other rheumatologic conditions. What comes with the fever (i.e. specific accompanying signs and symptoms) is essential to distinguish between such different diseases. This paper aims to provide an overview on the causes of recurrent fever in paediatrics, providing a practical guide to assist the paediatrician who needs to disentangle between different diagnoses.