STUDYING THE TRANSMISSION OF HEPATITIS-B VIRUS THROUGH SENSITIVITY ANALYSIS

Author:

ALI ASGHAR1,MUNIR MOHAMMAD2,HUSSAIN RASHIDA3,MEHMOOD SAIMA3

Affiliation:

1. Mirpur University of Science and Technology (MUST), 10250 Mirpur, Pakistan

2. Government Postgraduate College, 22010 Abbottabad, Pakistan

3. Mirpur University of Science and Technology (MUST), 10250 Mirpur, Pakistan / Government Postgraduate College, 22010 Abbottabad, Pakistan

Abstract

This paper presents the sensitivity analysis of an epidemiological model, SEIR, describing the transmission of Hepatitis B Virus. The classical sensitivities, the system sensitivity and the sensitivity norms of the model have been found. The sensitivities show that the susceptible individuals are majorly affected by the birth rate, contact rate, the rate at which the exposed individuals become infected and the fraction of the infected individuals in the population. System sensitivity describes the sensitivity of the whole model output with respect to all the parameters. The results of the classical sensitivities of the parameters are in agreement with the results given by the system sensitivities. The contact rate, β has the largest sensitivity norm and the exposed infected fraction of the population, t_1 has the least sensitivity norm. The qualitative and the quantitative sensitivity studies of the SEIR model reaffirm each other.

Publisher

Valahia University of Targoviste - Journal of Science and Arts

Reference20 articles.

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2. Blumberg, B.S., Hepatitis B: The hunt for a killer virus, Princeton University Press, 2002.

3. World Health Organization, Guidelines for the prevention care and treatment of persons with chronic hepatitis B infection: World Health Organization, 2015.

4. Zou, L., Zhang, W., Ruan, S., Journal of theoretical biology, 262(2), 330, 2010.

5. Parkin, D.M., Bray, F., Ferlay, J., Pisani, P. International Journal of Cancer, 94(2), 153, 2001.

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