Bioactive fragments of laminin and collagen chains: lesson from the testis

Author:

Li Huitao12,Liu Shiwen12,Wu Siwen12,Li Linxi12,Ge Renshan1,Cheng C Yan12

Affiliation:

1. 1The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

2. 2The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, USA

Abstract

Recent studies have shown that the testis is producing several biologically active peptides, namely the F5- and the NC1-peptides from laminin-γ3 and collagen α3 (IV) chain, respectively, that promotes blood–testis barrier (BTB) remodeling and also elongated spermatid release at spermiation. Also the LG3/4/5 peptide from laminin-α2 chain promotes BTB integrity which is likely being used for the assembly of a ‘new’ BTB behind preleptotene spermatocytes under transport at the immunological barrier. These findings thus provide a new opportunity for investigators to better understand the biology of spermatogenesis. Herein, we briefly summarize the recent findings and provide a critical update. We also present a hypothetical model which could serve as the framework for studies in the years to come.

Publisher

Bioscientifica

Subject

Cell Biology,Obstetrics and Gynaecology,Endocrinology,Embryology,Reproductive Medicine

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