Affiliation:
1. Department of Internal Medicine and Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
Abstract
Thyroid hormone (TH) is crucial for development and metabolism of many tissues. The physiological relevance and therapeutic potential of TH analogs have gained attention in the field for many years. In particular, the relevance and use of 3,3′,5-triiodothyroacetic acid (Triac, TA3) has been explored over the last decades. Although TA3 closely resembles the bioactive hormone T3, differences in transmembrane transport and receptor isoform-specific transcriptional activation potency exist. For these reasons, the application of TA3 as a treatment for resistance to TH (RTH) syndromes, especially MCT8 deficiency, is topic of ongoing research. This review is a summary of all currently available literature about the formation, metabolism, action and therapeutic applications of TA3.
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism
Reference414 articles.
1. Homozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature;Journal of Clinical Endocrinology and Metabolism,2012
2. 9 years follow-up of a patient with pituitary form of resistance to thyroid hormones (PRTH): comparison of two treatment periods of D-thyroxine and triiodothyroacetic acid (TRIAC);Journal of Pediatric Endocrinology and Metabolism,2009
3. Therapeutic applications of thyroid hormone analogues in resistance to thyroid hormone (RTH) syndromes;Molecular and Cellular Endocrinology,2017
4. Thyronamines and derivatives: physiological relevance, pharmacological actions and future research directions;Thyroid,2016
5. Thyroid status and effects of 3,5,3′ triiodothyroacetic acid and fenproporex in genetically lean and obese female rats;Biochemical Pharmacology,1980
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