Therapeutic potential of mesenchymal stem cells for diabetes-Reference-Cited by-同舟云学术

Therapeutic potential of mesenchymal stem cells for diabetes

Published:2017-10 Issue:3 Volume:59 Page:R109-R120
ISSN:0952-5041
Container-title:Journal of Molecular Endocrinology
language:
Short-container-title:

Author:

Moreira Alvaro¹,Kahlenberg Samuel¹,Hornsby Peter²

Affiliation:

1. 1Department of Pediatrics, University of Texas Health Science Center-San Antonio, San Antonio, Texas, USA

2. 2Department of Physiology, Texas Research Park Campus, Barshop Institute for Longevity and Aging Studies, San Antonio, Texas, USA

Abstract

Mesenchymal stem cells (MSCs) are self-renewing multipotent cells that have the capacity to secrete multiple biologic factors that can restore and repair injured tissues. Preclinical and clinical evidence have substantiated the therapeutic benefit of MSCs in various medical conditions. Currently, MSCs are the most commonly used cell-based therapy in clinical trials because of their regenerative effects, ease of isolation and low immunogenicity. Experimental and clinical studies have provided promising results using MSCs to treat diabetes. This review will summarize the role of MSCs on tissue repair, provide emerging strategies to improve MSC function and describe how these processes translate to clinical treatments for diabetes.

Publisher

Bioscientifica

Subject

Endocrinology,Molecular Biology

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