Durable remission of Cushing's disease after OP'DDD treatment

Abstract

Abstract. A long-term remission of a case of Cushing's disease is described. The patient received medical therapy in the form of OP'DDD for 3 years without radiotherapy nor surgery. Clinical and laboratory remission was maintained for 7 years after discontinuation of drug therapy. In particular, a normal circadian rhythm of plasma cortisol and ACTH and normal suppressibility by low doses of dexamethasone were observed. The evolution of this case suggests that the most likely aetiology was a reversible hypothalamic disorder.