Insulin resistance in patients with polycystic ovaries: its relationship to body weight and androgen levels

Author:

Pasquali Renato,Casimirri Francesco,Venturoli Stefano,Paradisi Roberto,Mattioli Loretta,Melchionda Nazario,Labò Giuseppe

Abstract

Abstract. Using a combined infusion of somatostatin, insulin and glucose, insulin resistance was assessed in vivo in two groups of females with polycystic ovaries (PCO), obese (OB-PCO) and normal weight (NO-PCO) and in two groups of matched (for age, sex and body mass index) controls (OB and NO). A steady state plasma glucose (SSPG) and insulin (SSPI) was attained after 90 min. OB-PCO and NO-PCO showed higher SSPG with respect to matched controls. The SSPG levels were related to body mass index (r = 0.69; P < 0.001). The SSPG values were significantly correlated with the fasting insulin levels (r = 0.47; P < 0.003). Gonadotrophin and steroid peripheral blood concentrations were also evaluated in the PCO females. A significant correlation was found between the SSPG values and the dehydroepiandrosterone sulphate levels (r = 0.46; P < 0.05) and between the fasting insulin levels and the androstenedione concentrations (r = 0.64; P <0.01). 0.01). Moreover, significant correlation coefficients were found between the glucose to insulin ratio and the A (r = −0.59; P < 0.01) and the DHEA-S (r = −0.50; P <0.05) plasma levels. Finally, no relationship between body mass index and A or DHEA-s levels was found in PCO females considered as a group. We conclude that insulin resistance is present in females with PCO and it is mainly dut to the presence of obesity, but other factors such as androgen levels, probably of adrenal sources, must be considered as a cause.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 92 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3