Endocrine, metabolic and cardiovascular responses to adrenaline after abdominal surgery
Author:
Hilsted J.,Wilken-Jensen C.,Birch K.,Nielsen M. Damkjær,Holst J. J.,Kehlet H.
Abstract
Abstract.
Adrenaline-induced changes in heart rate, blood pressure, plasma adrenaline and noradrenaline, cortisol, glucagon, insulin, cAMP, glucose, lactate, glycerol and β-hydroxybutyrate were studied preoperatively and 4 and 24 h after skin incision in 8 patients undergoing elective cholecystectomy. Late postoperative responses of blood glucose, plasma cAMP, lactate and glycerol to adrenaline infusion were reduced, whereas other responses were unaffected. Blood glucose appearance and disappearance rate as assessed by [3H]3-glucose infusion was unchanged pre- and postoperatively. The increase in glucose appearance rate following adrenaline was similar pre- and postoperatively. These findings suggest that several β-receptor-mediated responses to adrenaline are reduced after abdominal surgery.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
1 articles.
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