Author:
Fowler K J,Wong L H,Griffiths B K,Sibson M C,Reed S,Choo K H A
Abstract
Centromere protein B is a highly conserved constitutive protein found at centromeres. Gene knockout studies in mice have unexpectedly identifiedCenpbas a candidate gene involved in uterine function. The present study further explores the role ofCenpbin mice by intermatingCenpb-null mice over several generations. Breeding studies and analysis of uterine tissue indicate thatCenpb-null mice lose reproductive fitness over a number of generations due to a significant reduction in endometrial glands. These results suggest thatCenpbmay play an important function in the short- and long-term maintenance of uterine integrity.
Subject
Cell Biology,Obstetrics and Gynecology,Endocrinology,Embryology,Reproductive Medicine
Cited by
7 articles.
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