Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1-Reference-Cited by-同舟云学术

Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1

Published:2023-01-01 Issue:1 Volume:70 Page:
ISSN:0952-5041
Container-title:Journal of Molecular Endocrinology
language:
Short-container-title:

Author:

Zamboni Michela¹,Strimpakos Georgios¹,Poggiogalle Eleonora²,Donini Lorenzo M²,Civitareale Donato¹^ORCID

Affiliation:

1. Institute of Biochemistry and Cell Biology, National Council of Research, Monterotondo, Rome, Italy

2. Department of Experimental Medicine – Medical Pathophysiology, Food Science and Endocrinology Section, Sapienza University of Rome, Rome, Italy

Abstract

Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher BMI values. Although these data are supported by many clinical and epidemiological studies, our knowledge is very scarce at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling downregulates the expression of thyroid-specific transcription factor 2 (TTF-2/FoxE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FoxE1 gene expression is mediated by adipocyte signaling.

Publisher

Bioscientifica

Subject

Endocrinology,Molecular Biology

Link

https://jme.bioscientifica.com/downloadpdf/journals/jme/70/1/JME-22-0129.xml

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