CONN'S SYNDROME: THE EFFECT OF AMPHENONE

Abstract

ABSTRACT A case of primary aldosteronism is described which was associated with a marked left kidney atrophy. This patient showed hypertension, hypokalaemia, hypochloraemic alkalosis with urinary sodium and potassium loss. The inhibition of aldosterone secretion by the administration of amphenone and the associated changes in the urinary and blood electrolytes made it possible to focus attention to the mineralocorticoid secretion of the adrenal in this case, since it induced a reversion to normal of the abnormal biochemical blood picture. The patient died suddenly of a cerebrovascular accident. At autopsy, a left adrenal adenoma, weighing 13 g, mainly containing cells resembling those of the zona glomerulosa, was found.