Brown adipose tissue activity is reduced in women with polycystic ovary syndrome

Author:

Flávia R Oliveira12,Mamede Marcelo3,Bizzi Mariana F4,Ana Luiza L Rocha1,Ferreira Cláudia N5,Gomes Karina B6,Cândido Ana L4,Reis Fernando M1

Affiliation:

1. 1Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

2. 2Odete Valadares Maternity Hospital, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil

3. 3Department of Anatomy and Imaging, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

4. 4Department of Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

5. 5Technical College, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

6. 6Department of Clinical and Toxicological Analyses, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

Abstract

Objective To evaluate whether brown adipose tissue (BAT) activity is altered in women with polycystic ovary syndrome (PCOS), and whether BAT activity correlates with plasma levels of irisin, a myokine that can induce BAT formation. Design We performed a cross-sectional study including women with PCOS (n = 45) and a healthy control group (n = 25) matched by age and body mass index (BMI). Methods BAT activity was measured using 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by a validated enzyme immunoassay. Results Total BAT activity was significantly reduced in women with PCOS (maximal standardized uptake value (SUVmax): median 7.4 g/mL, interquartile range 0.9–15.4) compared to controls (median 13.0 g/mL, interquartile range 4.7–18.4, P = 0.047). However, this difference was no longer significant after adjustment for waist circumference, a surrogate marker of central adiposity. In the PCOS group, BAT activity correlated negatively with BMI (Spearman’s r = −0.630, P = 0.000) and waist circumference (r = −0.592, P = 0.000) but not with plasma irisin levels. Conclusions BAT activity was reduced in women with PCOS possibly due to increased central adiposity. In PCOS women, BAT activity did not correlate with plasma irisin levels.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

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