2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma

Author:

Lebbink Chantal A1,Links Thera P2ORCID,Czarniecka Agnieszka3,Dias Renuka P4,Elisei Rossella5,Izatt Louise6,Krude Heiko7,Lorenz Kerstin8,Luster Markus9,Newbold Kate10,Piccardo Arnoldo11,Sobrinho-Simões Manuel12,Takano Toru13,Paul van Trotsenburg A S14,Verburg Frederik A15,van Santen Hanneke M1ORCID

Affiliation:

1. Wilhelmina Children’s Hospital and Princess Máxima Center, Utrecht, The Netherlands

2. Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

3. The Oncologic and Reconstructive Surgery Clinic, M. Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, Gliwice, Poland

4. Department of Paediatric Endocrinology and Diabetes, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom

5. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

6. Department of Clinical Genetics, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom

7. Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin, Berlin, Germany

8. Department of Visceral, Vascular and Endocrine Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany

9. Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany

10. Thyroid Therapy Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom

11. Department of Nuclear Medicine, EO Ospedali Galliera, Genoa, Italy

12. University Hospital of São João, Medical Faculty and Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal

13. Thyroid Center, Rinku General Medical Center, Osaka, Japan

14. Department of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands

15. Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

Abstract

At present, no European recommendations for the management of pediatric thyroid nodules and differentiated thyroid carcinoma (DTC) exist. Differences in clinical, molecular, and pathological characteristics between pediatric and adult DTC emphasize the need for specific recommendations for the pediatric population. An expert panel was instituted by the executive committee of the European Thyroid Association including an international community of experts from a variety of disciplines including pediatric and adult endocrinology, pathology, endocrine surgery, nuclear medicine, clinical genetics, and oncology. The 2015 American Thyroid Association Pediatric Guideline was used as framework for the present guideline. Areas of discordance were identified, and clinical questions were formulated. The expert panel members discussed the evidence and formulated recommendations based on the latest evidence and expert opinion. Children with a thyroid nodule or DTC require expert care in an experienced center. The present guideline provides guidance for healthcare professionals to make well-considered decisions together with patients and parents regarding diagnosis, treatment, and follow-up of pediatric thyroid nodules and DTC.

Publisher

Bioscientifica

Subject

Endocrinology, Diabetes and Metabolism

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