Reversal of fortune: estrogen receptor-β in endometriosis-Reference-Cited by-同舟云学术

Reversal of fortune: estrogen receptor-β in endometriosis

Published:2016-08 Issue:2 Volume:57 Page:F23-F27
ISSN:0952-5041
Container-title:Journal of Molecular Endocrinology
language:
Short-container-title:

Author:

Simmen Rosalia C M¹,Kelley Angela S²

Affiliation:

1. 1Department of Physiology and BiophysicsUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

2. 2Department of Obstetrics and GynecologyUniversity of Michigan Health System, Ann Arbor, Michigan, USA

Abstract

Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic lesions. Alterations in the expression of estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) accompany the conversion of resident endometrial cells within the normal uterine environment to ectopic lesions located in extrauterine sites. Recent studies highlighted in this focused review linked ERβ to dysregulation of apoptotic and inflammatory networks involving novel interacting partners in endometriosis. The elucidation of these nongenomic actions of ERβ using human cells and mouse models is an important step in understanding key regulatory pathways that are disrupted leading to disease establishment and progression.

Publisher

Bioscientifica

Subject

Endocrinology,Molecular Biology

Reference21 articles.

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2. Pathogenesis and pathophysiology of endometriosis

3. Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model

4. Steroid receptor and aromatase expression in baboon endometriotic lesions

5. A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium

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