ÉTUDE DE L'ACTIVITÉ BIOLOGIQUE IN VITRO DES HORMONES GONADOTROPES

Abstract

ABSTRACT Temperature has been shown to have a profound effect on the incorporation of 14C acetate into steroids by rat corpus luteum in vitro. The variations of temperature affected to a different extent the labelling of progesterone and androstenedione. Differences were also found between cyclic and pseudopregnancy corpora lutea studied at different temperatures and stimulated or not by pregnant mare serum gonadotrophin (PMS) in vitro. These results are consistent with the hypothesis that progesterone and androstenedione are synthesized through different pathways. They also suggest that lactogenic hormone stimulates specifically the synthesis of androstenedione.