QUANTITATIVE ASSAY OF THE SUPPRESSIVE EFFECT OF SYNTHETIC CORTICOIDS IN MAN
Author:
Boss N.,Kluge F.,Müller O. A.,Pickardt C. R.,Scriba P. C.
Abstract
ABSTRACT
The suppressive effect of synthetic corticoids on the human hypothalamic-pituitary-adrenal axis was analyzed by determining the integral differences of the circadian serum cortisol levels between control subjects (N = 25) and subjects receiving different single oral doses of prednisolone (N = 29) or fluocortolone (N = 36). Linear log dose-response curves were obtained by this procedure with the indices of precision for prednisolone of λ = 0.221 and for fluocortolone of λ = 0.149. With this method it is possible to compare the suppressive effect of different corticoids. The relative suppressive potency of corticoids should not be expressed by ratios or factors, but rather by log dose-response curves of the type: response = b · log dose ± a.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
4 articles.
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