STEROID HORMONE PRODUCTION FOLLOWING ADRENAL STIMULATION IN THE RHESUS MONKEY

Abstract

ABSTRACT The adrenal response to the infusion of various corticotrophin (ACTH) preparations and other hormones in the orchiectomized rhesus monkey has been measured by the excretion of 17-hydroxycorticosteroids, 17-ketosteroids, and 11-deoxy-17-ketosteroids. No difference was found in the response to genuine or synthetic ACTH. A response was demonstrated with 0.8 U or more of ACTH per 24 hours. No adrenal response was observed to infusions of various gonadotrophins, growth hormone, prolactin, α-melanocyte stimulating hormone, and thyroid stimulating hormone. Angiotensin selectively stimulated aldosterone excretion. No evidence was found for any selective stimulation of adrenal androgen production.