Author:
Bergman F.,Heedman P.-A.,van der Linden W.
Abstract
ABSTRACT
Syrian hamsters were treated for one month with a diet containing 5 mg/100 g 1-thyroxine. If after this treatment with thyroxine the hamsters were fed a thyroxine-free diet with cholestyramine for one month, the thyroid glands were normal while in the controls they still had a »resting« appearance. In a second experiment hamsters were given a diet containing 131I 1-thyroxine with and without cholestyramine. A significantly smaller fraction of the radioactivity was found in the carcass, exclusive of the gastrointestinal tract, of the cholestyramine treated animals than in that of the controls. In a third experiment hamsters were injected intravenously with 131I 1-thyroxine and given diets with and without cholestyramine. The radioactivity of the cholestyramine treated animals was found to decrease more rapidly than that of the controls due to a larger excretion of radioactive material in the faeces. It is concluded that cholestyramine diminishes the absorption and promotes the excretion in the faeces of thyroxine or its iodine containing derivates.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
23 articles.
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