Author:
Okada Hiroji,Amatsu Minoru,Ishihara Sadanao,Tokuda Gen-ichi
Abstract
ABSTRACT
The effects of oral administration of synthetic progestins on the urinary oestrogen excretion were examined. 17α-ethynyl-19-nortestosterone (ENT) or 17α-ethynyl-estr-4-en-17β-ol (EEL) caused a significant rise of oestrogen output in urine. It appeared that the increased output of oestrogen was due to the conversion of ENT or EEL to ethynyl-oestradiol (EE2). Such a conversion of progestin was also observed with 17α-methyl-19-nortestosterone.
To obtain the direct evidence for the conversion of ENT to EE2, human placental homogenates were incubated in vitro first with 19-nortestosterone. The approximate yield of oestrone was 20 percent of that observed with testosterone. However, a conversion of ENT to EE2 was not detected.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
35 articles.
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