AUFHEBUNG DER TESTOSTERONPROPIONAT-INDUZIERTEN UNTERDRÜCKUNG DES VAGINAL-ZYKLUS UND DER OVULATION DURCH EIN ANTIANDROGEN WIRKSAMES STEROID AN RATTEN

Abstract

ABSTRACT It was examined in how far the inhibition of the vaginal cycle and of the ovulation caused by testosterone propionate, 6α-methyl-17β-hydroxyprogesterone-acetate (MAP), 17α-ethynyl-19-nor-testosterone-acetate (ANTA), oestradiol and progesterone was influenced by simultaneous administration of an anti-androgenically effective steroid (1,2α-methylene-6-chloro-pregna-4,6-diene-17α-ol-3,20-dione = Cyproterone). The anti-ovulatory activity of testosterone propionate and MAP is considerably diminished under the influence of Cyproterone. The activity of ANTA is only influenced to a very slight extent, while that of oestradiol and progesterone is not influenced at all. The action of Cyproterone is explained with a blocking of the androgenreceptors of the hypothalamus. Interpretation of the results eventually give new indications that androgens are not directly involved in intraovarian mechanisms preparing ovulation. Possible application for clinical use in particular cases of sterility in women are discussed.