ENDOCRINE PROFILE OF A NONSTEROIDAL ANTIANDROGEN N-(3,5-DIMETHYL-4-ISOXAZOLYLMETHYL)PHTHALIMIDE (DIMP)-Reference-Cited by-同舟云学术

ENDOCRINE PROFILE OF A NONSTEROIDAL ANTIANDROGEN N-(3,5-DIMETHYL-4-ISOXAZOLYLMETHYL)PHTHALIMIDE (DIMP)

Published:1973-03 Issue:3 Volume:72 Page:604-614
ISSN:0804-4643
Container-title:Acta Endocrinologica
language:
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Author:

Boris Alfred,Scott John W.,DeMartino Louis,Cox Donald C.

Abstract

ABSTRACT DIMP, N-(3,5-Dimethyl-4-isoxazolylmethyl)phthalimide, blocked the stimulatory effects of testosterone, androstenedione, nortestosterone, fluoxymesterone and dihydrotestosterone on sex accessory gland weights in castrated male rats. The compound also antagonized the uterotrophic effect of testosterone and inhibited the antigonadotrophic activity of testosterone. DIMP did not manifest androgenic, antigonadotrophic, uterotrophic or progestational activities, and did not antagonize the uterotrophic activity of oestradiol in the rat nor the endometrial response to progesterone in the oestrogen-primed rabbit.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

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