Comparative immunohistochemical studies of γ-melanocyte stimulating hormone (γ-MSH) and adrenocorticotrophic hormone (ACTH) in the bovine and human pituitaries

Abstract

Abstract. Comparative immunohistochemical localization of γ-melanocyte stimulating hormone (γ-MSH) and adrenocorticotrophic hormone (ACTH1-24) was studied on bovine and human pituitaries. By the combination of peroxidase labelled antibody method and 'mirror' sections, it was clearly demonstrated that γ-MSH and ACTH were present in the same cells in pars distalis and in pars intermedia or zona intermedia of the bovine and human pituitaries, respectively. Our studies further supported the concept of the production of precursor molecule for these peptides in pars distalis as well as in pars (zona) intermedia.