ADRENAL HYPERAEMIA CAUSED BY CORTICOTROPHIN

Abstract

ABSTRACT Using 131I-labelled serum albumin it was found that in hypophysectomized rats, ACTH caused an increase in the adrenal blood content. This increase was particularly marked after the administration of a long acting ACTH preparation, which caused the blood content of the adrenals to rise from about 25% of the adrenal weight to 40—50%. The period during which this hyperaemia was maintained, increased with increasing doses of Zn-ACTH. Repeated doses of the free peptide also had a cumulative effect.