Abstract
ABSTRACT
Alkali-denatured pepsin and pepsinogen, at concentrations corresponding to 0.5 units of insulin per milliliter, act like insulin in the intact rat diaphragm. They stimulate the cellular uptake of 3-0-methyl glucose and promote the synthesis of glycogen from glucose. The insulin-like action of digestive enzzymes is considered to be a consequence of their evolutionary descent from a protein precursor in common with that of insulin. The nature of the cellular response to insulin and insulin-like enzymes may depend on the degree to which these molecules are able to complement a membrane-sited receptor to form an active enzyme.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
28 articles.
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