ZUR EXTRARENALEN WIRKUNG VON MINERALOCORTICOIDEN

Abstract

ABSTRACT It was assumed that mineralocorticoids are capable of changing the binding properties of acid mucopolysaccharides. To test this hypothesis, the sodium and potassium contents of tissues containing mucopolysaccharides (cartilage, aorta, skin) were investigated in rats at three different conditions, i. e. after adrenalectomy, salt loading, administration of mineralocorticoids or the combination thereof. Heart muscle with its prevalent cellular tissue served as basis for comparison. The results point to a possible extrarenal action of fluorohydrocortisone and deoxycorticosterone on the cell membranes. Though extrarenal factors of the hormone action effecting the interstitium could be detected, they were difficult to differentiate from those on the cells proper as the investigated cartilage, aorta and skin tissue cannot be considered cell-free.