Author:
Bell E. T.,Harkness R. A.,Loraine J. A.,Russell G. F. M.
Abstract
ABSTRACT
Serial studies of endocrine function have been performed in four female patients and one male patient with anorexia nervosa during treatment by refeeding. None of the females menstruated or ovulated at any stage of the investigation. Hormone assay changes were most marked in severely ill patients.
Refeeding produced an increase in human pituitary gonadotrophin (HPG) output in two patients in whom pretreatment levels were below or at the lower end of the normal range.
In these two subjects a rise in HPG levels during refeeding was associated with an increase in the output of 17-hydroxycorticosteroids and 17-oxosteroids. In the remaining three patients the effect of this treatment on the excretion of these hormones was less marked. Excretion values for dehydroepiandrosterone increased during refeeding in three subjects.
In the females the relative proportions of oestriol, oestrone and oestradiol in urine were altered by refeeding, proportionally more oestriol being excreted.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
42 articles.
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