Abstract
ABSTRACT
5 menopausal and 12 oophorectomized women aged 31 to 56 were divided in two comparable groups. The first group was treated with a daily dose of 5 mg of 6-methyl-6-dehydro-17α-acetoxyprogesterone (megestrol acetate) continuously, and the second group received a daily dose of 0.1 mg of 17α-ethynyl-oestradiol-3-methylether (mestranol) also continuously. The patients were observed for 12 to 63 weeks. The excretion of total pituitary gonadotrophins was determined every 2 to 4 weeks during treatment and every week during the period after the end of treatment.
During treatment with megestrol acetate it was characteristic of all 9 patients in this group that the excretion of gonadotrophins showed very marked variations from time to time, but in none of the 9 patients was there any significant suppression of the gonadotrophins.
During treatment with mestranol there was a significant suppression of the gonadotrophins in 7 out of the 8 patients in this group, and in 3 patients the excretion became undetectable. The suppression of gonadotrophins occurred gradually over a period of about 4 months. The gonadotrophin output reached pre-treatment levels 2 to 9 weeks (an average of 5 weeks) after treatment was discontinued.
This effect of megestrol acetate and mestranol respectively on the excretion of total pituitary gonadotrophins was compared with the effect of a combination of both substance reported in a previous paper. With this combination it seems to be the oestrogen exclusively which causes the suppression of total gonadotrophins. No synergistic effect of the oestrogen and the gestagen was found.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
4 articles.
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