EXCRETION OF GONADOTROPHINS DURING GESTAGEN- AND OESTROGEN-TREATMENT

Author:

Starup J.

Abstract

ABSTRACT 5 menopausal and 12 oophorectomized women aged 31 to 56 were divided in two comparable groups. The first group was treated with a daily dose of 5 mg of 6-methyl-6-dehydro-17α-acetoxyprogesterone (megestrol acetate) continuously, and the second group received a daily dose of 0.1 mg of 17α-ethynyl-oestradiol-3-methylether (mestranol) also continuously. The patients were observed for 12 to 63 weeks. The excretion of total pituitary gonadotrophins was determined every 2 to 4 weeks during treatment and every week during the period after the end of treatment. During treatment with megestrol acetate it was characteristic of all 9 patients in this group that the excretion of gonadotrophins showed very marked variations from time to time, but in none of the 9 patients was there any significant suppression of the gonadotrophins. During treatment with mestranol there was a significant suppression of the gonadotrophins in 7 out of the 8 patients in this group, and in 3 patients the excretion became undetectable. The suppression of gonadotrophins occurred gradually over a period of about 4 months. The gonadotrophin output reached pre-treatment levels 2 to 9 weeks (an average of 5 weeks) after treatment was discontinued. This effect of megestrol acetate and mestranol respectively on the excretion of total pituitary gonadotrophins was compared with the effect of a combination of both substance reported in a previous paper. With this combination it seems to be the oestrogen exclusively which causes the suppression of total gonadotrophins. No synergistic effect of the oestrogen and the gestagen was found.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Ultrastructural changes found in the endometrium of women using megestrol acetate for contraception;Contraception;1972-03

2. Suppression of Urinary Excretion of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) by Medroxyprogesterone Acetate;The Journal of Clinical Endocrinology & Metabolism;1969-04

3. Mode of action of contraceptive drugs*;American Journal of Obstetrics and Gynecology;1968-01

4. Pharmacological Control of Reproduction in Women;Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques;1968

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