METABOLISM OF PREGNENOLONE-3-SULPHATE IN THE PERFUSED DOG LIVER

Author:

Voigt K. D.,Tamm J.,Volkwein U.,Schedewie H.

Abstract

ABSTRACT Pregnenolone-sulphate (400 mg) was perfused through isolated dog livers. The following steroids were isolated in the perfusate: pregnenolone, progesterone, dehydroepiandrosterone, androst-5-ene-diol and the two steroid conjugates, i. e. pregnenolone-sulphate and dehydroepiandrosterone-sulphate. Two »free« steroids and one steroid conjugate could not be characterized. A tentative scheme for the metabolic pathways of pregnenolone-sulphate is presented.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. 3β-Hydroxy-Δ5-C19- and C21-steroid oxidoreductase activity in rat liver;Steroids;1972-04

2. Metabolismus von Steroid-Konjugaten, VIII. In-vivo-Perfusion des menschlichen Gehirns mit [7α-3H] Androstenolon-sulfatid;Hoppe-Seyler´s Zeitschrift für physiologische Chemie;1971-01

3. The Biochemistry of the 3β-Hydroxy-Δ 5-Steroid Sulfates;Chemical and Biological Aspects of Steroid Conjugation;1970

4. The Biochemistry of the 3β—Hydroxy—∆ 5—Steroid Sulfates;Chemical and Biological Aspects of Steroid Conjugation;1970

5. Tables for the identification of steroid conjugates;Chromatographic Reviews;1969-06

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