Author:
Ermini M.,Carpino F.,Russo M.,Benagiano G.
Abstract
ABSTRACT
In vitro diffusion of [14C] megestrol acetate (MA) was studied before and after the subcutaneous insertion of polydimethylsiloxane implants (PDS) in the human. A certain period of equilibration before diffusion becomes constant is required for newly prepared capsules as well as for those extracted from the subcutaneous tissue within six months of the insertion. On the other hand, in vitro diffusion from capsules that have remained in the human for periods over one year, does not require any equilibration. Up to six months, the release in vitro of megestrol acetate was not significantly changed, whereas it was greatly decreased when capsules were re-incubated following sojourn in the subcutaneous tissue for 18 or 24 months.
A continuous wall of newly formed fibrotic tissue, proliferated in a circular manner was found around the capsules in all the cases studied. This fibrillary tissue was then surrounded by a fibrous adipose layer containing granulomas and giant-cells of the foreign body type.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献