Abstract
ABSTRACT
Studies of serum lipids and of the fatty acid composition of the main fractions were performed in a 17-year-old girl following a large single oral intake of 1-thyroxine.
Cholesterol and phospholipids values decreased markedly. These changes were followed by pronounced disturbances in the fatty acid composition of these fractions, with a lowering of linoleic acid, and an increase in arachidonic acid percentages. Other changes were increased oleic acid in the cholesterol esters, and increased eicosatrienoic acid in the phospholipids. The changes were in accordance with findings made in patients with long standing thyrotoxicosis. They support the hypothesis that increased synthesis of arachidonic from linoleic acid contributes to the linoleic acid deficiency seen in thyrotoxicosis.
The serum lipids and values for fatty acid composition showed a tendency to return to the original levels within 10 to 15 days. However, in the phospholipids some of the very long-chained fatty acids decreased during the 40-day observation period.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献