EFFECT OF HEPARIN ON INSULIN SECRETION INDUCED BY GLUCOSE IN DOGS

Author:

Orosz L.,Fischer U.,Hommel H.,Fiedler H.

Abstract

ABSTRACT In anaesthetized dogs, heparin given intravenously in a dose of 100 IU/kg 10 min before an ivGTT (0.5 g/kg) inhibited glucose-stimulated insulin secretion as measured in portal and peripheral venous blood. Thus glucose assimilation is reduced. However there was a considerable antilipolytic action of the small quantity of secreted insulin as shown by the diminution of FFA concentration.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Absence of Effect of Heparin on Insulin Secretion;Artificial Organs;1988-04

2. 9 The artificial pancreas;Clinics in Endocrinology and Metabolism;1977-07

3. Drugs affecting blood clotting and fibrinolysis;Side Effects of Drugs Annual;1977

4. Studies With the Autotransplanted Ovine Pancreas: Glucagon and Insulin Secretion;Australian Journal of Biological Sciences;1976

5. Effect of sodium warfarin on plasma insulin estimations;General Pharmacology: The Vascular System;1976-01

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