SERUM PROTEIN-BOUND IODINE AND SERUM THYROXINE DURING PERPHENAZINE THERAPY

Abstract

ABSTRACT Four out of 19 patients treated with perphenazine who were investigated in 1962, and 5 out of 31 patients who were investigated in 1966 had a raised PBI. The increase was most marked in the patients investigated in 1962. Measurements of dialysable thyroxine revealed that the increase was not due to an increase in thyroxine-binding globulin. All 50 patients had normal serum thyroxine as estimated by Murphy's method. Most probably the increase in PBI was due to the fact that the perphenazine tablets contain an iodine compound, which in some subjects may become bound to the serum proteins.