ÜBER DEN EINFLUSS DES ERNÄHRUNGSZUSTANDES DER RATTE AUF DEN CORTISON- UND KOHLENHYDRATSTOFFWECHSEL IN DER LEBER

Abstract

ABSTRACT Fasting reduces the rate of cortisone inactivation in rat liver slices; the inhibition of cortisone inactivation is greater in male than in female rats. The decline in steroid reduction occurs only if the glucose-6-phosphate content of the liver has reached one tenth of the control value. A significant decrease in liver glycogen and a twofold increase in liver glucose-6-phosphatase-activity alone are without influence on the rate of cortisone reduction. During the fasting periods of 42 and 60 hours the activity of the glucose-6-phosphate-dehydrogenase remains unchanged. Intraperitoneal injection of glucose normalizes the rate of cortisone inactivation in the course of 2 hours. The disturbed carbohydrate metabolism is not the only cause of the decreased cortisone reduction; almost one third can be accounted for by the lowered activity of the microsomal 5α-reductase.