EFFECT OF THYROTROPHIN RELEASING HORMONE (TRH) IN PATIENTS WITH PITUITARY DISORDERS

Author:

Lindholm J.,Dige-Petersen H.,Hummer L.,Rasmussen P.,Korsgaard O.

Abstract

ABSTRACT The secretion and biological activity of thyroid stimulating hormone (TSH) were studied in 22 patients with a pituitary tumour (17 acromegalics and 5 patients with a chromophobe adenoma) and in 36 hypophysectomized patients (16 acromegalics and 20 with a chromophobe adenoma). Thyroid function was assessed by serum thyroxine (T4), serum triiodothyronine (T3), and thyroxine-binding globulin (TBG) concentration. Serum TSH was measured before and after injection of TSH releasing hormone (TRH), and in 19 hypophysectomized patients the T3 response after TRH was measured. In addition a TRH test was performed 1–2 weeks after surgery in 11 patients. The basal serum TSH did not differ from euthyroid control values in any of the groups and no late effect of hypophysectomy was observed. Subnormal peak TSH values were seen in 10 out of 37 euthyroid patients, whereas 9 out of 11 hypothyroid patients responded normally. Hypophysectomy caused an immediate but transient decrease in peak TSH in patients with a chromophobe adenoma only. The rise in serum T3 after TRH was significantly lower in hypophysectomized patients than in controls. An increase in TSH was followed by a T3 response in all patients except in 4 out of 8 euthyroid acromegalics. In patients operated on for a chromophobe adenoma the T3 response was correlated with serum T4, whereas this was not the case in acromegalics.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

Cited by 12 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Pseudotumor cerebri. A theory on etiology and pathogenesis;Acta Neurologica Scandinavica;2009-01-29

2. Assessment of pituitary function;Acta Neurologica Scandinavica;2009-01-29

3. The Pituitary-Thyroid Axis in Patients with Pituitary Disorders;Hormone and Metabolic Research;1989-07

4. Hypothalamic-pituitary-thyroid axis in acromegaly;Journal of Endocrinological Investigation;1983-08

5. PITUITARY FUNCTION IN PATIENTS WITH EVIDENCE OF SPONTANEOUS DISAPPEARANCE OF A PITUITARY ADENOMA;Clinical Endocrinology;1983-06

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