Author:
Genazzani A. R.,Felber J. P.,Fioretti P.
Abstract
ABSTRACT
Plasma immunoreactive ACTH (I. R. ACTH), immunoreactive human chorionic somatomammotrophin (I. R. HCS) and 11-OH steroids levels were measured during normal and pathological pregnancies. Plasma I. R. ACTH levels were found to be above normal during pregnancy, with a slight decrease near term. This observation correlates well with the recent description of human chorionic corticotrophin (HCC), i. e. a factor of placental origin possessing a high biological adrenocorticotrophic activity and presenting partial immunological cross-reaction with human ACTH. The 11-OH steroids levels, as measured by a fluorimetric method, increased regularly during pregnancy but, unlike ACTH, reached their highest value near term, I. R. HCS increased progressively until term when a slight decrease was observed.
In pathological pregnancies, I. R. ACTH levels behaved like other placental hormones. On the contrary, 11-OH steroids levels remained generally unmodified. Treatment with high doses of prednisolone caused no inhibition of the plasma I. R. ACTH and of plasma 11-OH steroids levels. These data suggest placental autonomy of the secretion of HCC and low adrenal responsiveness to endogenous ACTH variations throughout pregnancy.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
14 articles.
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