ERFOLGREICHE BEHANDLUNG EINES FALLES VON CUSHING-SYNDROM MIT o,p-DDD

Abstract

ABSTRACT o,p-DDD was tried as an adrenal inhibitor in a patient with Cushing's syndrome due to non-tumorous adrenal hyperfunction. Administration of a total dose of 382 grams of o,p-DDD during a period of 105 days resulted in a complete remission of the previously existing symptoms of hypercorticism. The elevated excretion of urinary steroids decreased to normal during the course of o,p-DDD administration. Symptoms of hypoadrenalism did not develop during the four months of treatment. Remission in that patient is being maintained by intermittent administration of o,p-DDD Though liver function tests remained normal throughout the course of treatment marked fatty changes of the liver were dedected in material obtained by needle biopsy. As a further symptom of toxicity of o,p-DDD anorexia was observed.