URINARY VOLUME AND EXCRETION OF OESTROGENS IN LATE PREGNANCY

Abstract

ABSTRACT The relationship between urinary volume and oestrone, 17β-oestradiol and oestriol was studied initially within the range of spontaneous variation and subsequently with the aid of water loads and diuretics. The spontaneous variations in urinary output showed no definite correlation with the excretion of oestrogens, while massive hydration led to increased excretion. With hydrochlorothiazide a clear positive correlation was obtained. The authors regard the results as evidence in favour of the view that reabsorption of the above-mentioned oestrogens occurs in the region of the proximal tubules.