Author:
Barnafi L.,Larraguibel R.
Abstract
ABSTRACT
The in vitro effect of progesterone and oestrogens on the spontaneous and oxytocin-induced activity of the pregnant and non-pregnant human myometrium was studied.
Oestrogens as well as progesterone blocked the spontaneous and oxytocininduced contractions 10–20 min after the steroids were added to the bath. The inhibitory effect was dose-dependent and reversible. Oestradiol-17β and diethylstilboestrol were approximately 10 times more active than progesterone.
The possible mechanism of action of oestrogens and progesterone are discussed.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
7 articles.
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