Author:
Croughs R. J. M.,Maingay D.,Touber J. L.,de Ruyter H. A.,van Aalst R.
Abstract
ABSTRACT
Insulin-131I metabolism was studied in 10 patients receiving insulin therapy and in 12 untreated subjects (7 normal controls, 4 diabetics treated exclusively with oral hypoglycaemic agents and 1 untreated diabetic).
In the subjects not receiving insulin therapy, insulin-131I was rapidly accumulated in the liver and kidneys, and degradation was followed by rapid urinary excretion; in cases in which insulin therapy had induced antibody formation, degradation was inhibited.
In tracer studies using different animal insulins and human insulin, species-specific differences in combining with antibodies could be demonstrated both in vitro and in vivo.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
8 articles.
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