Author:
Adlkofer F.,Schleusener H.,Uher L.,Ananos A.,Brammeier C.
Abstract
ABSTRACT
Crude IgG of sera from 3 patients with Graves' disease, which contained LATS-activity and/or thyroid antibodies, was fractionated by isoelectric focusing in a pH-range between 6.0 to 10.0. LATS-activity was found in IgG-subfractions from pH 7.5 to 9.5, thyroglobulin antibodies and thyroid microsomal antibodies from pH 6.0 to 10.0. It was not possible to separate LATS-activity from the thyroid antibodies by this technique. The results indicate that LATS and the thyroid antibodies are heterogeneous and of polyclonal origin.
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
22 articles.
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