ACUTE ENZYME HISTOCHEMICAL CHANGES IN THE ZONA GLOMERULOSA OF THE RAT ADRENAL CORTEX

Author:

Elema J. D.,Hardonk M. J.,Arends A.

Abstract

ABSTRACT In order to determine whether the increased enzyme histochemical activity of the zona glomerulosa of the rat adrenal cortex, as seen after peritoneal dialysis with 5 % glucose, is mediated by the renin-angiotensin system, and whether the increased activity as seen after total nephrectomy is a direct effect of changes in potassium balance, the effect of suppression of the renin-angiotensin system and of depletion of body potassium on these findings was investigated. Suppression of renin-angiotensin system activity and depletion of body potassium was accomplished by treatment of the rats with 2.5 mg deoxycorticosterone acetate given subcutaneously daily for 4 weeks. This treatment resulted in a delayed activation of the zona glomerulosa after peritoneal dialysis and a complete lack of reaction after total nephrectomy; the findings support the above mentioned assumptions about the manner in which the zona glomerulosa is activated in these experimental conditions.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

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