ALDOSTERONAUSSCHEIDUNG UND ELEKTROLYTHAUSHALT UNTER PITRESSINEINWIRKUNG BEI NICHT HYDRIERTEN NORMALEN VERSUCHSPERSONEN

Abstract

ABSTRACT 11 normal subjects were kept on a standard diet containing 120–150 mval Na and 60–70 mval K pro die. The total fluid supply was 1500–2000 ml in 24 h. After a 6 days control period during which continuously the haematocrit values, Na, K and Cl in serum, the excretion of Na, K, Cl and aldosterone in urine, and the body weight have been checked, the subjects were given intramuscular injections each 5 IU Pitressin in oil. Further studies of the above values on the following 6–7 days showed no changement of the Na, K and Cl concentrations in serum under pitressin and also a little drop of the hematocrit values. Likewise the excretion of Na, K and Cl in urine and the body weight remained unchanged. On the contrary there was a significant drop of the aldosterone excretion in urine of about 50 % on the 2. and 3. day after pitressin was given followed by an increase above the control values. The possible mechanism of the decreased aldosterone excretion is discussed. Since no retention of fluid and no corresponding increase of intravasal fluid volume were found an inhibition of the adrenoglomerulotrophin, and by that a decreased secretion of aldosterone by the adrenal cortex is suggested.