VERLAUFSUNTERSUCHUNGEN DES WASSERHAUSHALTES BEI ADIPÖSEN UNTER TRIJODTHYRONINTHERAPIE MIT BERÜCKSICHTIGUNG DER ALDOSTERONAUSSCHEIDUNG IM HARN UND EINES ANTIDIURETISCHEN PRINZIPS IM SERUM (ADH)

Abstract

ABSTRACT In 4 patients with excessive obesity (78.4—160.8 kg body-weight) the following determinations were performed before and during triiodo-thyronine treatment: the aldosterone excretion in the urine, the serum concentration of antidiuretic substances (ADH according to Buchborn), the osmolality, sodium, potassium and chloride in plasma and urine, the total and extracellular fluid compartments, the glomerular filtration rate (by inulin clearance), the renal plasma flow, and the circulating plasma volume. During triiodothyronine treatment, the previously increased levels of aldosterone in the urine and the serum ADH decreased towards the normal range. The glomerular filtration rate and the renal plasma flow, both as a rule significantly reduced in obesity, as well as the circulating plasma volume were increased. In all 4 cases, the administration of triiodo-thyronine was followed by distinct natriuresis, reduction of the cholesterol level in the serum, and an increase of the basal metabolic rate. A statistically significant relation could be demonstrated between the aldosterone excretion rate in the urine and the ADH concentration of the serum on the one hand and the circulating plasma volume on the other. This relation was also found between the aldosterone excretion and ADH concentration in the serum.