EFFECT OF CORTICOTROPHIN AND CORTISONE ON THE INCORPORATION OF 3H-THYMIDINE INTO THE DEOXYRIBONUCLEIC ACIDS (DNA) OF THE REGENERATING LIVER IN THE WHITE RAT-Reference-Cited by-同舟云学术

EFFECT OF CORTICOTROPHIN AND CORTISONE ON THE INCORPORATION OF 3H-THYMIDINE INTO THE DEOXYRIBONUCLEIC ACIDS (DNA) OF THE REGENERATING LIVER IN THE WHITE RAT

Published:1968-09 Issue:1 Volume:59 Page:10-22
ISSN:0804-4643
Container-title:Acta Endocrinologica
language:
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Author:

Guzek Jan W.

Abstract

ABSTRACT Both cortisone and ACTH inhibit the incorporation of 3H-thymidine into the DNA of parenchymatous cells in the regenerating rat liver. In addition, the mitotic activity of hepatocytes is markedly impaired. It is assumed that the suppression of mitoses in the regenerating rat liver, caused by cortisone or ACTH, is due to a direct or indirect interference with DNA synthesis.

Publisher

Bioscientifica

Subject

Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism

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